Amarasekara Dulshara Sachini, Yu Jiyeon, Rho Jaerang
Department of Bioscience and Biotechnology, College of Biological Sciences and Biotechnology, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon 305-764, Republic of Korea.
J Immunol Res. 2015;2015:832127. doi: 10.1155/2015/832127. Epub 2015 May 4.
Bone remodeling is a lifelong process in vertebrates that relies on the correct balance between bone resorption by osteoclasts and bone formation by osteoblasts. Bone loss and fracture risk are implicated in inflammatory autoimmune diseases such as rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel disease, and systemic lupus erythematosus. The network of inflammatory cytokines produced during chronic inflammation induces an uncoupling of bone formation and resorption, resulting in significant bone loss in patients with inflammatory autoimmune diseases. Here, we review and discuss the involvement of the inflammatory cytokine network in the pathophysiological aspects and the therapeutic advances in inflammatory autoimmune diseases.
骨重塑是脊椎动物的一个终身过程，它依赖于破骨细胞的骨吸收和成骨细胞的骨形成之间的正确平衡。骨质流失和骨折风险与类风湿性关节炎、强直性脊柱炎、炎症性肠病和系统性红斑狼疮等炎症性自身免疫疾病有关。慢性炎症期间产生的炎症细胞因子网络会导致骨形成和吸收解偶联，从而导致炎症性自身免疫疾病患者出现显著的骨质流失。在此，我们综述并讨论炎症细胞因子网络在炎症性自身免疫疾病病理生理学方面的作用以及治疗进展。
