Mundy G R
University of Texas Health Science Center, San Antonio.
J Periodontal Res. 1991 May;26(3 Pt 2):213-7. doi: 10.1111/j.1600-0765.1991.tb01647.x.
Bone is remodelled by the coordinated actions of osteoclasts and osteoblasts. Cellular remodelling occurs in discrete packets of bone, and is regulated by local cytokines produced in the environment of the remodelling cells. These cytokines are secreted by immune cells and by bone cells. In addition, some growth regulatory factors are incorporated into the noncollagenous bone matrix and are released in an active form when bone is stimulated to resorb. Complex interactions between these cytokines and their target cells are responsible for the normal delicate balance between bone resorption and bone formation, and disorders of bone loss are due to imbalances between the rates of resorption and formation.
骨骼通过破骨细胞和成骨细胞的协同作用进行重塑。细胞重塑发生在离散的骨包块中，并受重塑细胞环境中产生的局部细胞因子调节。这些细胞因子由免疫细胞和骨细胞分泌。此外，一些生长调节因子被整合到非胶原骨基质中，并在骨受到刺激进行吸收时以活性形式释放。这些细胞因子与其靶细胞之间的复杂相互作用负责骨吸收与骨形成之间正常的微妙平衡，而骨质流失紊乱则是由于吸收和形成速率之间的失衡所致。
