García-Posadas Laura, Contreras-Ruiz Laura, Soriano-Romaní Laura, Dartt Darlene A, Diebold Yolanda
Ocular Surface Group (L.G.-P., L.S.-R., Y.D.), Institute for Applied Ophthalmobiology (IOBA), University of Valladolid, Valladolid, Spain; Networking Research Center on Bioengineering (L.G.-P., L.S.-R., Y.D.), Biomaterials and Nanomedicine (CIBER-BBN); Department of Ophthalmology (L.C.-R.), Boston University School of Medicine, Boston, MA; Schepens Eye Research Institute/Massachusetts Eye and Ear (D.A.D.), Harvard Medical School, Boston, MA; and Department of Ophthalmology (D.A.D.), Harvard Medical School, Boston, MA.
Eye Contact Lens. 2016 Mar;42(2):83-90. doi: 10.1097/ICL.0000000000000158.
This review focuses on conjunctival goblet cells and their essential function in the maintenance of eye health. The main function of goblet cells is to produce and secrete mucins that lubricate the ocular surface. An excess or a defect in those mucins leads to several alterations that makes goblet cells central players in maintaining the proper mucin balance and ensuring the correct function of ocular surface tissues. A typical pathology that occurs with mucous deficiency is dry eye disease, whereas the classical example of mucous hyperproduction is allergic conjunctivitis. In this review, we analyze how goblet cell number and function can be altered in these diseases and in contact lens (CL) wearers. We found that most published studies focused exclusively on the goblet cell number. However, recent advances have demonstrated that, along with mucin secretion, goblet cells are also able to secrete cytokines and respond to them. We describe the effect of different cytokines on goblet cell proliferation and secretion. We conclude that it is important to further explore the effect of CL wear and cytokines on conjunctival goblet cell function.
本综述聚焦于结膜杯状细胞及其在维持眼部健康中的重要功能。杯状细胞的主要功能是产生和分泌润滑眼表的黏蛋白。这些黏蛋白的过量或缺陷会导致多种改变，使杯状细胞成为维持适当黏蛋白平衡及确保眼表组织正常功能的关键因素。黏液缺乏时出现的典型病症是干眼症，而黏液分泌过多的经典例子是过敏性结膜炎。在本综述中，我们分析了在这些疾病以及佩戴隐形眼镜（CL）的人群中杯状细胞数量和功能是如何改变的。我们发现，大多数已发表的研究仅专注于杯状细胞数量。然而，最近的进展表明，除了黏蛋白分泌外，杯状细胞还能够分泌细胞因子并对其作出反应。我们描述了不同细胞因子对杯状细胞增殖和分泌的影响。我们得出结论，进一步探究佩戴隐形眼镜和细胞因子对结膜杯状细胞功能的影响很重要。
