Rao U Subrahmanyeswara, Mayhew Susan L, Rao Prema S
Department of Pharmaceutical Sciences, Appalachian College of Pharmacy, Oakwood, VA 23631, USA.
Department of Pharmacy Practice, Appalachian College of Pharmacy, Oakwood, VA 23631, USA.
Pharmacogenomics. 2015 Jul;16(8):905-11. doi: 10.2217/pgs.15.50. Epub 2015 Jun 12.
Sequencing of the human genome and the evidence correlating specific genetic variations to diseases have opened up the potential of genomics to more effective and less harmful interventions of human diseases. A wealth of pharmacogenomics knowledge is in place for the practice of precision medicine. However, this knowledge is not fully realized in clinical practice. One reason for this impasse is the lack of in-depth understanding of the potential of pharmacogenomics among the healthcare professionals. Pharmacists are the point-of-care providers and are expected to advise clinicians on matters relating to the implementation of pharmacogenomics in patient care. However, current pharmacogenomics instruction in pharmacy schools fails to produce pharmacists with the required knowledge or practical training in this discipline. In this perspective, we provide several strategies to overcome limitations faced by pharmacy schools. Once implemented, pharmacy schools will produce precision medicine-ready pharmacists.
人类基因组测序以及将特定基因变异与疾病相关联的证据，开启了基因组学在人类疾病干预方面更有效且危害更小的潜力。大量的药物基因组学知识已具备，可用于精准医疗实践。然而，这些知识在临床实践中并未得到充分应用。造成这种僵局的一个原因是医疗保健专业人员对药物基因组学潜力缺乏深入了解。药剂师是直接护理提供者，预计要就药物基因组学在患者护理中的实施相关事宜为临床医生提供建议。然而，目前药学院的药物基因组学教学未能培养出具备该学科所需知识或实践培训的药剂师。从这个角度出发，我们提供了几种策略来克服药学院面临的局限性。一旦实施，药学院将培养出能够胜任精准医疗的药剂师。
