Institute of Clinical Pathology, University Hospital, Geneva, Switzerland.
Department of Internal Medicine, University Hospital, Geneva, Switzerland.
Clin Kidney J. 2012 Feb;5(1):59-62. doi: 10.1093/ckj/sfr176.
Light chain deposit disease (LCDD) is a rare condition caused by deposition of overproduced monoclonal light chains and has been frequently related to multiple myeloma or lymphocytic disorders. LCDD in association with human immunodeficiency virus (HIV) has only been described twice in the literature and is thought to result from HIV direct/indirect effects on B and T-cell populations, leading to chronic immune activation with paraprotein production. We report a renal LCDD case diagnosed at autopsy in a severely immunodepressed HIV patient and analyse renal histopathology of 18 HIV patients who had an autopsy in our department between 2000 and 2010.
轻链沉积病（LCDD）是一种由过量产生的单克隆轻链沉积引起的罕见疾病，常与多发性骨髓瘤或淋巴细胞疾病有关。文献中仅描述过两次与人类免疫缺陷病毒（HIV）相关的 LCDD，据认为是 HIV 对 B 和 T 细胞群体的直接/间接影响所致，导致慢性免疫激活和副蛋白产生。我们报告了一例在严重免疫抑制的 HIV 患者尸检中诊断的肾脏 LCDD 病例，并分析了 2000 年至 2010 年间在我科进行尸检的 18 例 HIV 患者的肾脏组织病理学。
