Biochemistry and Molecular Parasitology Research Group, Department of Parasitology, University of Granada, Campus de Fuentenueva, Granada, Spain.
Biochemistry and Molecular Parasitology Research Group, Department of Parasitology, University of Granada, Campus de Fuentenueva, Granada, Spain; Centre for Immunology and Infection (CII), Biology Department, University of York, York, UK.
Trends Parasitol. 2015 Aug;31(8):350-6. doi: 10.1016/j.pt.2015.05.004. Epub 2015 Jun 9.
Some of the most crucial phenotypic aspects of parasites, such as an antigen-coated surface, parasite sexual differentiation, virulence, and drug resistance, rely on adaptive plasticity and/or stochastic events. At a population level, cell to cell variability represents an avenue for rapid response to drastic changes in the environment. Single cell approaches can be used to unravel the different strategies used by parasites to survive in the context of regulated transcriptional control (apicomplexa) or in its absence (kinetoplastids).
寄生虫的一些最关键的表型方面，如抗原覆盖的表面、寄生虫的性分化、毒力和耐药性，依赖于适应性可塑性和/或随机事件。在种群水平上，细胞间的可变性为快速应对环境剧烈变化提供了途径。单细胞方法可用于揭示寄生虫在受调控的转录控制（顶复门生物）或缺乏转录控制的情况下（动基体目生物）生存所使用的不同策略。
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