Catricalà Eleonora, Della Rosa Pasquale A, Plebani Valentina, Perani Daniela, Garrard Peter, Cappa Stefano F
Institute for Advanced Study-IUSS Pavia, Pavia, Italy.
Institute of Molecular Bioimaging and Physiology, National Research Council (IBFM-CNR), Milan, Italy.
Brain Lang. 2015 Aug;147:58-65. doi: 10.1016/j.bandl.2015.05.007. Epub 2015 Jun 11.
The failure to name an object in Alzheimer's disease (AD) and in the semantic variant of the primary progressive aphasia (sv-PPA) has been generally attributed to semantic memory loss, with a progressive degradation of semantic features. Not all features, however, may have the same relevance in picture naming. We analyzed the relationship between picture naming performance and the loss of semantic features in patients with AD with or without naming impairment, with sv-PPA and in matched controls, assessing the role of distinctiveness, semantic relevance and feature type (sensorial versus non-sensorial) with a sentence verification task. The results showed that distinctive features with high values of semantic relevance were lost only in all patients with naming impairment. The performance on the sensorial distinctive features with high relevance was the best predictor of naming performance only in sv-PPA, while no difference between sensorial and non-sensorial features was found in AD patients.
在阿尔茨海默病（AD）和原发性进行性失语的语义变异型（sv-PPA）中，无法说出物体名称通常归因于语义记忆丧失，语义特征逐渐退化。然而，并非所有特征在图片命名中都具有相同的相关性。我们分析了有或没有命名障碍的AD患者、sv-PPA患者以及匹配对照组中图片命名表现与语义特征丧失之间的关系，通过句子验证任务评估独特性、语义相关性和特征类型（感官特征与非感官特征）的作用。结果表明，只有所有有命名障碍的患者才会失去具有高语义相关性的独特特征。具有高相关性的感官独特特征的表现仅在sv-PPA中是命名表现的最佳预测指标，而在AD患者中未发现感官特征和非感官特征之间存在差异。
