Sun-Wada Ge-Hong, Wada Yoh
Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kohdo, Kyotanabe, Kyoto 610-0395, Japan.
Division of Biological Science, Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan.
Biochim Biophys Acta. 2015 Oct;1847(10):1166-72. doi: 10.1016/j.bbabio.2015.06.010. Epub 2015 Jun 11.
The vacuolar H(+)-ATPase (V-ATPase) was first identified as an electrogenic proton pump that acidifies the lumen of intra- and extracellular compartments. The acidic pH generated by V-ATPase is important for a wide range of cellular processes as well as acidification-independent processes such as secretion and membrane fusion. In addition to these housekeeping functions, recent studies implicate V-ATPase in the direct regulation and function of signaling pathways. In this review, we describe recent findings on the functions of V-ATPase in growth regulation and tissue physiology.
液泡H(+)-ATP酶（V-ATP酶）最初被鉴定为一种使细胞内和细胞外区室腔酸化的生电质子泵。V-ATP酶产生的酸性pH值对于广泛的细胞过程以及诸如分泌和膜融合等不依赖酸化的过程都很重要。除了这些管家功能外，最近的研究表明V-ATP酶参与信号通路的直接调节和功能。在本综述中，我们描述了关于V-ATP酶在生长调节和组织生理学中的功能的最新发现。
