在基于细胞的软骨治疗中使用软骨祖细胞的潜在益处和局限性。
Potential benefits and limitations of utilizing chondroprogenitors in cell-based cartilage therapy.
作者信息
Jayasuriya Chathuraka T, Chen Qian
机构信息
Department of Orthopedics, Warren Alpert Medical School of Brown University , Providence, RI , USA.
出版信息
Connect Tissue Res. 2015;56(4):265-71. doi: 10.3109/03008207.2015.1040547.
Abstract
Chondroprogenitor cells are a subpopulation of multipotent progenitors that are primed for chondrogenesis. They are believed to have the biological repertoire to be ideal for cell-based cartilage therapy. In addition to summarizing recent advances in chondroprogenitor cell characterization, this review discusses the projected pros and cons of utilizing chondroprogenitors in regenerative medicine and compares them with that of pre-existing methods, including autologous chondrocyte implantation (ACI) and the utilization of bone marrow derived mesenchymal stem cells (MSCs) for the purpose of cartilage tissue repair.
摘要
软骨祖细胞是多能祖细胞的一个亚群，已做好软骨形成的准备。它们被认为具有理想的生物学特性，适合用于基于细胞的软骨治疗。除了总结软骨祖细胞特性研究的最新进展外，本综述还讨论了在再生医学中使用软骨祖细胞的预期利弊，并将其与现有方法进行比较，包括自体软骨细胞植入（ACI）以及利用骨髓间充质干细胞（MSC）进行软骨组织修复。
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