Noguchi T, Mizumoto R
Rinsho Byori. 1989 Sep;37(9):994-8.
The possibility of extended hepatectomy was examined clinically and experimentally, with special reference to relation between remnant liver dysfunction and lipid peroxidation. Clinical study: When the functional reserve of the remnant liver prior to hepatectomy was below the critical level, both serum phospholipase A2 and plasma lipid peroxide increased and severe hepatic insufficiency occurred. Experimental study in dogs: The amount of lipid peroxide in the plasma and remnant liver increased more after 84% hepatectomy than after 70% hepatectomy, causing significant impairment of the remnant liver function. To prevent hepatic dysfunction after hepatectomy, Coenzyme Q10, an antioxidant and a membrane stabilizer, were administered. These substances reduced the increase of lipid in the plasma and remnant liver, and restored the liver function with subsequent good regeneration. The results suggest that the administration of Coenzyme Q10 may be useful for recovery of liver function and a more favorable prognosis following the extended hepatectomy.
我们对扩大肝切除术的可能性进行了临床和实验研究，特别关注残余肝功能与脂质过氧化之间的关系。临床研究：肝切除术前残余肝的功能储备低于临界水平时，血清磷脂酶A2和血浆脂质过氧化物均升高，并出现严重肝功能不全。犬实验研究：84%肝切除术后血浆和残余肝中的脂质过氧化物量比70%肝切除术后增加得更多，导致残余肝功能明显受损。为预防肝切除术后肝功能障碍，给予抗氧化剂和膜稳定剂辅酶Q10。这些物质减少了血浆和残余肝中脂质的增加，并恢复了肝功能，随后肝脏实现良好再生。结果表明，辅酶Q10的应用可能有助于扩大肝切除术后肝功能的恢复和获得更良好的预后。
