Zhou Yanming, Lin Jincan, Wu Lupeng, Li Bin, Li Hua
Department of Hepatobiliary & Pancreatovascular Surgery, First affiliated Hospital of Xiamen University; Oncologic Center of Xiamen, Xiamen, China.
Department of Digestive Diseases, First Xiamen Hospital, Fujian Medical University, Xiamen, China.
BMC Gastroenterol. 2015 Jun 16;15:68. doi: 10.1186/s12876-015-0300-8.
Delayed gastric emptying (DGE) is one of the most frequent complications after pancreaticoduodenectomy (PD). This meta-analysis aimed to evaluate the effect of antecolic versus retrocolic reconstruction of gastro/duodenojejunostomy on DGE after PD.
Randomized controlled trials (RCTs) comparing antecolic versus retrocolic reconstruction of gastro/duodenojejunostomy on DGE after PD were eligible for inclusion. Pooled estimates of treatment effect were calculated using either the fixed effects model or random effects model.
Five RCTs involving 534 randomized patients were eligible. The comparison of DGE showed no significant difference (odds ratio, 0.66; 95% confidence interval, 0.32 to 1.33; P = 0.24). The antecolic and retrocolic groups also had comparable outcomes for clinical parameters related to DGE, other complications, hospital mortality, and length of hospital stay.
The route of gastro/duodenojejunostomy reconstruction has no impact on DGE after PD. Therefore, the choice of reconstruction route should be selected according to the surgeon's preference.
胃排空延迟(DGE)是胰十二指肠切除术(PD)后最常见的并发症之一。本荟萃分析旨在评估胃/十二指肠空肠吻合术结肠前重建与结肠后重建对PD术后DGE的影响。
比较PD术后胃/十二指肠空肠吻合术结肠前重建与结肠后重建对DGE影响的随机对照试验(RCT)符合纳入标准。使用固定效应模型或随机效应模型计算治疗效果的合并估计值。
5项RCT符合标准,涉及534例随机分组患者。DGE比较显示无显著差异(优势比,0.66;95%置信区间,0.32至1.33;P = 0.24)。结肠前组和结肠后组在与DGE相关的临床参数、其他并发症、医院死亡率和住院时间方面也有相似的结果。
胃/十二指肠空肠吻合术重建路径对PD术后DGE无影响。因此,重建路径的选择应根据外科医生的偏好来决定。