Robertson Janet, Hatton Chris, Emerson Eric, Baines Susannah
Centre for Disability Research, Division of Health Research, Lancaster University, LA1 4YT, United Kingdom.
Centre for Disability Research, Division of Health Research, Lancaster University, LA1 4YT, United Kingdom.
Seizure. 2015 Jul;29:46-62. doi: 10.1016/j.seizure.2015.03.016. Epub 2015 Mar 30.
Epilepsy is more common in people with intellectual disabilities than in the general population. However, reported prevalence rates vary widely between studies. This systematic review aimed to provide a summary of prevalence studies and estimates of prevalence based on meta-analyses.
Studies were identified via electronic searches using Medline, Cinahl and PsycINFO and cross-citations. Information extracted from studies was tabulated. Prevalence rate estimates were pooled using random effects meta-analyses and subgroup analyses were conducted.
A total of 48 studies were included in the tabulation and 46 studies were included in meta-analyses. In general samples of people with intellectual disabilities, the pooled estimate from 38 studies was 22.2% (95% CI 19.6-25.1). Prevalence increased with increasing level of intellectual disability. For samples of people with Down syndrome, the pooled estimate from data in 13 studies was 12.4% (95% CI 9.1-16.7), decreasing to 10.3% (95% CI 8.4-12.6) following removal of two studies focusing on older people. Prevalence increased with age in people with Down syndrome and was particularly prevalent in those with Alzheimer's/dementia.
Epilepsy is highly prevalent in people with intellectual disabilities. Services must be equipped with the skills and information needed to manage this condition.
癫痫在智障人群中比在普通人群中更为常见。然而，不同研究报告的患病率差异很大。本系统评价旨在总结患病率研究情况，并基于荟萃分析对患病率进行估计。
通过使用Medline、Cinahl和PsycINFO进行电子检索以及交叉引用确定研究。从研究中提取的信息制成表格。使用随机效应荟萃分析汇总患病率估计值，并进行亚组分析。
共有48项研究被列入表格，46项研究被纳入荟萃分析。在智障人群的一般样本中，38项研究的汇总估计患病率为22.2%（95%置信区间19.6 - 25.1）。患病率随智力残疾程度的增加而升高。对于唐氏综合征患者样本，13项研究数据的汇总估计患病率为12.4%（95%置信区间9.1 - 16.7），在剔除两项针对老年人的研究后降至10.3%（95%置信区间8.4 - 12.6）。唐氏综合征患者的患病率随年龄增长而升高，在患有阿尔茨海默病/痴呆症的患者中尤为普遍。
癫痫在智障人群中高度流行。服务机构必须具备管理这种疾病所需的技能和信息。
