Sharma Jyoti, Balakrishnan Lavanya, Datta Keshava K, Sahasrabuddhe Nandini A, Khan Aafaque Ahmad, Sahu Apeksha, Singhal Anish, Getnet Derese, Raju Rajesh, Chatterjee Aditi, Gowda Harsha, Keshava Prasad T S, Shankar Subramanian, Pandey Akhilesh
Institute of Bioinformatics, International Technology Park, Bangalore, 560066, India.
Manipal University, Madhav Nagar, Manipal, 576104, India.
J Cell Commun Signal. 2015 Sep;9(3):291-6. doi: 10.1007/s12079-015-0297-3. Epub 2015 Jun 16.
Interleukin-17 (IL-17) belongs to a relatively new family of cytokines that has garnered attention as the signature cytokine of Th17 cells. This cytokine family consists of 6 ligands, which bind to 5 receptor subtypes and induce downstream signaling. Although the receptors are ubiquitously expressed, cellular responses to ligands vary across tissues. The cytokine family is associated with various autoimmune disorders including rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, asthma and psoriasis in addition to being implicated in the pathogenesis of cancer. In addition, this family plays a role in host defense against bacterial and fungal infections. The signaling mechanisms of the IL-17 family of proinflammatory cytokines are not well explored. In this study, we present a resource of literature-annotated reactions induced by IL-17. The reactions are catalogued under 5 categories, namely; molecular association, catalysis, transport, activation/inhibition and gene regulation. A total of 93 molecules and 122 reactions have been annotated. The IL-17 pathway is freely available through NetPath, a resource of signal transduction pathways previously developed by our group.
白细胞介素-17（IL-17）属于一个相对较新的细胞因子家族，作为辅助性T细胞17（Th17）细胞的标志性细胞因子而备受关注。这个细胞因子家族由6种配体组成，它们与5种受体亚型结合并诱导下游信号传导。尽管这些受体在全身广泛表达，但细胞对配体的反应在不同组织中有所不同。除了与癌症的发病机制有关外，这个细胞因子家族还与各种自身免疫性疾病相关，包括类风湿性关节炎、多发性硬化症、炎症性肠病、哮喘和银屑病。此外，该家族在宿主抵御细菌和真菌感染中发挥作用。促炎细胞因子IL-17家族的信号传导机制尚未得到充分研究。在本研究中，我们提供了一份由IL-17诱导的文献注释反应资源。这些反应被归类为5类，即分子缔合、催化、转运、激活/抑制和基因调控。总共注释了93个分子和122个反应。IL-17信号通路可通过NetPath免费获取，NetPath是我们团队之前开发的信号转导通路资源。
