Wu Duo, Chen Xingyu, Chen Tianchan, Ding Chunmei, Wu Wei, Li Jianshu
College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, China.
State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China.
Sci Rep. 2015 Jun 16;5:11105. doi: 10.1038/srep11105.
Implant materials need to be highly biocompatible to avoid inflammation in clinical practice. Although biodegradable polymeric implants can eliminate the need for a second surgical intervention to remove the implant materials, they may produce acidic degradation products in vivo and cause non-bacterial inflammation. Here we show the strategy of "substrate-anchored and degradation-sensitive coatings" for biodegradable implants. Using poly(lactic acid)/hydroxyapatite as an implant material model, we constructed a layer-by-layer coating using pH-sensitive star polymers and dendrimers loaded with an anti-inflammatory drug, which was immobilised through a hydroxyapatite-anchored layer. The multifunctional coating can effectively suppress the local inflammation caused by the degradation of implant materials for at least 8 weeks in vivo. Moreover, the substrate-anchored coating is able to modulate the degradation of the substrate in a more homogeneous manner. The "substrate-anchored and degradation-sensitive coating" strategy therefore exhibits potential for the design of various self-anti-inflammatory biodegradable implant materials.
在临床实践中，植入材料需要具有高度的生物相容性以避免炎症。尽管可生物降解的聚合物植入物可以消除二次手术取出植入材料的需求，但它们可能在体内产生酸性降解产物并引发非细菌性炎症。在此，我们展示了一种用于可生物降解植入物的“底物锚定且降解敏感涂层”策略。以聚乳酸/羟基磷灰石作为植入材料模型，我们使用pH敏感的星形聚合物和负载抗炎药物的树枝状大分子构建了层层涂层，该涂层通过羟基磷灰石锚定层固定。这种多功能涂层能够在体内有效抑制植入材料降解引起的局部炎症至少8周。此外，底物锚定涂层能够以更均匀的方式调节底物的降解。因此，“底物锚定且降解敏感涂层”策略在设计各种自抗炎可生物降解植入材料方面具有潜力。
