Orthopaedic Research Lab, Department of Orthopaedics, University Hospital of Aarhus, Aarhus C, Denmark.
J Biomed Mater Res A. 2010 Dec 1;95(3):665-72. doi: 10.1002/jbm.a.32863.
It is well established in the field of biomaterials that hydroxyapatite (HA) may provide interesting osteoconductive properties. In this study, we investigated the osseointegrational effect of a 50/50 vol % composite of HA nanoparticles and poly-D,L-lactic acid (PDLLA) coated on model titanium bone implants in an in vivo animal model. The aim is to evaluate how the addition of HA to PDLLA may improve the bone formation and initial fixation of the implant. Two titanium implants coated with the PDLLA/HA composite and pure PDLLA, respectively, were implanted bilaterally in proximal part of humeri with a 2-mm peri-implant gap in 10 sheep. After 12 weeks, the remains of the coatings were present on 20.3 and 19.8% of PDLLA/HA composite- and PDLLA-coated implants, respectively. It was observed that newly formed bone (39.3%) and fibrous tissue (58.3%) had replaced the PDLLA/HA composite, whereas pure PDLLA was replaced almost completely by fibrous tissue (96.2%). Consequently, the PDLLA/HA composite-coated implants were better fixated as confirmed by push-out tests. Using quantification of peri-implant tissue and implant fixation as parameters, the present findings, therefore, clearly reveal that the addition of nanoparticulate HA to a PDLLA coating on titanium implants increases osseointegration.
在生物材料领域，羟基磷灰石（HA）具有良好的骨诱导特性已得到广泛证实。本研究通过体内动物模型，调查了 50/50vol%HA 纳米颗粒和聚-D,L-乳酸（PDLLA）复合涂层模型钛骨植入物的骨整合效果。目的是评估将 HA 添加到 PDLLA 中如何改善植入物的骨形成和初始固定。将分别涂有 PDLLA/HA 复合材料和纯 PDLLA 的两种钛植入物双侧植入 10 只绵羊肱骨近端，植入物周围有 2mm 的间隙。12 周后，在 PDLLA/HA 复合材料和 PDLLA 涂层植入物上分别有 20.3%和 19.8%的涂层残留。观察到新形成的骨（39.3%）和纤维组织（58.3%）取代了 PDLLA/HA 复合材料，而纯 PDLLA 几乎完全被纤维组织（96.2%）取代。因此，正如推出试验所证实的那样，PDLLA/HA 复合材料涂层植入物的固定效果更好。通过对植入物周围组织和植入物固定的定量，本研究结果清楚地表明，在钛植入物的 PDLLA 涂层中添加纳米级 HA 可增加骨整合。
