细胞因子介导的爱泼斯坦-巴尔病毒相关急性传染性单核细胞增多症期间血液树突状细胞丢失：对免疫失调的影响

Cytokine-Mediated Loss of Blood Dendritic Cells During Epstein-Barr Virus-Associated Acute Infectious Mononucleosis: Implication for Immune Dysregulation.

作者信息

Panikkar Archana, Smith Corey, Hislop Andrew, Tellam Nick, Dasari Vijayendra, Hogquist Kristin A, Wykes Michelle, Moss Denis J, Rickinson Alan, Balfour Henry H, Khanna Rajiv

机构信息

QIMR Centre for Immunotherapy and Vaccine Development, Tumour Immunology Laboratory, QIMR Berghofer Medical Research Institute School of Medicine, University of Queensland, Brisbane, Australia.

QIMR Centre for Immunotherapy and Vaccine Development, Tumour Immunology Laboratory, QIMR Berghofer Medical Research Institute.

出版信息

J Infect Dis. 2015 Dec 15;212(12):1957-61. doi: 10.1093/infdis/jiv340. Epub 2015 Jun 16.

DOI:10.1093/infdis/jiv340

PMID:26080368

Abstract

Acute infectious mononucleosis (IM) is associated with altered expression of inflammatory cytokines and disturbed T-cell homeostasis, however, the precise mechanism of this immune dysregulation remains unresolved. In the current study we demonstrated a significant loss of circulating myeloid and plasmacytoid dendritic cells (DCs) during acute IM, a loss correlated with the severity of clinical symptoms. In vitro exposure of blood DCs to acute IM plasma resulted in loss of plasmacytoid DCs, and further studies with individual cytokines showed that exposure to interleukin 10 could replicate this effect. Our data provide important mechanistic insight into dysregulated immune homeostasis during acute IM.

摘要

急性传染性单核细胞增多症（IM）与炎性细胞因子表达改变及T细胞稳态紊乱有关，然而，这种免疫失调的确切机制仍未明确。在本研究中，我们证实在急性IM期间循环髓样和浆细胞样树突状细胞（DCs）显著减少，这种减少与临床症状的严重程度相关。体外将血液DCs暴露于急性IM血浆导致浆细胞样DCs减少，对单个细胞因子的进一步研究表明，暴露于白细胞介素10可重现这种效应。我们的数据为急性IM期间免疫稳态失调提供了重要的机制性见解。