Xu Yu-yue, Cheng Lin, Yang Tian-feng, Zhang Quan-li, Chang Chuan-jie, Feng Cui, Liu Wei-zhong
Zhong Yao Cai. 2014 Dec;37(12):2204-6.
To investigate the secondary metabolites from Penicillium raistrickii.
Compounds were isolated and purified by normal and reverse phase silica gel, Sephadex LH-20 gel column chromatography and RP-HPLC. Their structures were established by means of spectral techniques and physicochemical properties.
Twelve compounds were identified as pestafolide A(II), 3-methoxy-4-methyl-2,4-dien-pentanoic acid (2),p-hydroxy phenylacetamide (3),2-(2-hydroxy propanamido) benzamide (4), nicotinic acid (5), thymine (6), uracil (7) cyclo (Gly-Ala) (8), (22E,24R)-3β,5α,9α-trihydroxy ergosta-7,22-diene-6-one (9), cerevisterol (10), ergosterol (11) and ergosterol peroxide (12).
All compounds are isolated from Penicillium raistrickii for the first time.
研究赖氏青霉的次生代谢产物。
通过正相和反相硅胶柱色谱、葡聚糖凝胶LH-20柱色谱及反相高效液相色谱对化合物进行分离纯化。借助光谱技术和理化性质确定其结构。
鉴定出12种化合物，分别为pestafolide A（II）、3-甲氧基-4-甲基-2,4-二烯戊酸（2）、对羟基苯乙酰胺（3）、2-（2-羟基丙酰胺基）苯甲酰胺（4）、烟酸（5）、胸腺嘧啶（6）、尿嘧啶（7）、环（甘氨酸-丙氨酸）（8）、（22E，24R）-3β，5α，9α-三羟基麦角甾-7,22-二烯-6-酮（9）、酵母甾醇（10）、麦角甾醇（11）和麦角甾醇过氧化物（12）。
所有化合物均首次从赖氏青霉中分离得到。
