Ras: structural details to guide direct targeting.
作者信息
Mattos Carla
机构信息
Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, USA.
出版信息
Aging (Albany NY). 2015 Jun;7(6):344-5. doi: 10.18632/aging.100754.
Abstract
摘要
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本文引用的文献
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Direct Attack on RAS: Intramolecular Communication and Mutation-Specific Effects.直接攻击 RAS：分子内通讯和突变特异性效应。
Clin Cancer Res. 2015 Apr 15;21(8):1810-8. doi: 10.1158/1078-0432.CCR-14-2148.
2
Allosteric effects of the oncogenic RasQ61L mutant on Raf-RBD.致癌性RasQ61L突变体对Raf-RBD的变构效应。
Structure. 2015 Mar 3;23(3):505-516. doi: 10.1016/j.str.2014.12.017. Epub 2015 Feb 12.
3
The Ras-Membrane Interface: Isoform-specific Differences in The Catalytic Domain.Ras与膜的界面：催化结构域中的亚型特异性差异
Mol Cancer Res. 2015 Apr;13(4):595-603. doi: 10.1158/1541-7786.MCR-14-0535. Epub 2015 Jan 7.
4
DRoP: a water analysis program identifies Ras-GTP-specific pathway of communication between membrane-interacting regions and the active site.DRoP：一个水质分析程序可识别膜相互作用区域与活性位点之间 Ras-GTP 特异性通讯途径。
J Mol Biol. 2014 Feb 6;426(3):611-29. doi: 10.1016/j.jmb.2013.10.036. Epub 2013 Nov 2.
5
A comprehensive survey of Ras mutations in cancer.癌症中 Ras 突变的全面调查。
Cancer Res. 2012 May 15;72(10):2457-67. doi: 10.1158/0008-5472.CAN-11-2612.
6
Analysis of binding site hot spots on the surface of Ras GTPase.分析 Ras GTPase 表面的结合位点热点。
J Mol Biol. 2011 Nov 4;413(4):773-89. doi: 10.1016/j.jmb.2011.09.011. Epub 2011 Sep 16.
7
Allosteric modulation of Ras positions Q61 for a direct role in catalysis.变构调节 Ras 使其 Q61 位置有利于直接参与催化。
Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):4931-6. doi: 10.1073/pnas.0912226107. Epub 2010 Mar 1.
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