Nishino H, Ono A, Matsuda A, Ueda T
Faculty of Pharmaceutical Science, Hokkaido University, Sapporo, Japan.
Nucleic Acids Symp Ser. 1989(21):123-4.
Oligodeoxyribonuclotides containing N6-methoxyadenine (mo6A), a promutagenic base, were synthesized. The Tm values and thermodynamic parameters for double strand formation of d(CCTGGTAmo6ACAGGTCC) have been measured. The order of the base-pair stability was A-T greater than mo6A-C approximately equal to mo6A-T greater than A-C.
合成了含有N6-甲氧基腺嘌呤（mo6A，一种促诱变碱基）的寡脱氧核糖核苷酸。已测量了d(CCTGGTAmo6ACAGGTCC)双链形成的熔解温度（Tm）值和热力学参数。碱基对稳定性顺序为A-T大于mo6A-C约等于mo6A-T大于A-C。
