在噬菌体G4单链DNA复制起点发现的可相互转换的发夹结构。
Interconvertible hairpin structure found in the replication origin of phage G4 single-stranded DNA.
作者信息
Hirao I, Nishimura Y, Ishida M, Watanabe K, Miura K
机构信息
Department of Industrial Chemistry, Faculty of Engineering, University of Tokyo, Japan.
出版信息
Nucleic Acids Symp Ser. 1989(21):13-4.
We found a synthetic GCGAAAGC fragment with a mobility greater than that of other oligodeoxyribonucleotides in gel electrophoresis to take on a stable hairpin structure possessing two terminal G-C base pairs. The GCGAAAGC sequence is also found in the replication origin of phage G4 single-stranded DNA, but the hairpin structure originally proposed differs from that of the GCGAAAGC fragment we have studied. Possibility of rearrangement of the secondary structure in the replication origin of phage G4 was examined in relation to its replication initiation mechanism.
我们发现一个合成的GCGAAAGC片段，在凝胶电泳中其迁移率大于其他寡脱氧核糖核苷酸，该片段呈现出具有两个末端G-C碱基对的稳定发夹结构。GCGAAAGC序列也存在于噬菌体G4单链DNA的复制起点中，但最初提出的发夹结构与我们所研究的GCGAAAGC片段的发夹结构不同。结合噬菌体G4的复制起始机制，研究了其复制起点二级结构重排的可能性。
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