Vraníková Barbora, Gajdziok Jan
Ceska Slov Farm. 2015 Spring;64(1-2):7-13.
Bioavailability can be defined as the rate and range of active ingredient absorption, when it becomes available in the systemic circulation or at the desired site of drug action, respectively. Drug bioavailability after oral administration is affected by anumber of different factors, including physicochemical properties of the drug, physiological aspects, the type of dosage form, food intake, biorhythms, and intra- and interindividual variability of the human population. This article is the first from the series dealing with the bioavailability and methods leading to its improvement. The aim of the present paper is to provide an overview of aspects influencing the rate of bioavailability after oral administration of the active ingredient. Subsequentarticles will provide detailed descriptions of methods used for dug bioavailability improvement, which are here only summarized.
生物利用度可分别定义为活性成分在体循环中或在药物作用的预期部位可用时的吸收速率和范围。口服给药后的药物生物利用度受多种不同因素影响，包括药物的物理化学性质、生理因素、剂型类型、食物摄入、生物节律以及人群的个体内和个体间变异性。本文是关于生物利用度及其改善方法系列文章中的第一篇。本文的目的是概述影响活性成分口服给药后生物利用度速率的各个方面。后续文章将详细描述用于改善药物生物利用度的方法，本文仅作总结。
