Svoboda Martin, Blahova Jana, Jarkovsky Jiri, Zacharda Adam, Hajkova Suzana, Vanhara Jonas, Vasek Jan
Ruminant and Swine Clinic, Faculty of Veterinary Medicine, University of Veterinary Sciences Brno, Brno, Czech Republic.
Department of Animal Protection and Welfare and Veterinary Public Health, Faculty of Veterinary Hygiene and Ecology, University of Veterinary Sciences Brno, Brno, Czech Republic.
Vet Med (Praha). 2023 Apr 26;68(4):145-151. doi: 10.17221/21/2023-VETMED. eCollection 2023 Apr.
The aim of the study was to compare the efficacy of the intranasal and parenteral administration of azaperone in order to achieve pig sedation. A total of 32 weaned piglets divided into 4 groups (8 piglets in each group) were used. Group A was injected intramuscularly (i.m.) with azaperone (Stresnil, 40 mg/ml inj.; Elanco Animal Health) at a dose of 2 mg/kg of body weight (b.w.). Group B received a dose of 2 mg/kg b.w. of azaperone intranasally. Group C was given azaperone intranasally at a dose of 4 mg/kg b.w. Group D was given 1 ml of saline intranasally and served as the control group. The response to the defined stimulus (a blunt blow of a metal rod into a metal edge of a pen), the degree of salivation, movement level, body temperature and serum azaperone concentration were included in the trial. We found that in order to induce an adequate level of sedation comparable to the standard method of application, i.e., 2 mg/kg b.w. i.m., the intranasal administration of azaperone at a dose of 4 mg/kg body weight is required.
本研究的目的是比较氮哌酮鼻内给药和肠胃外给药在猪镇静方面的疗效。总共使用了32只断奶仔猪，分为4组（每组8只仔猪）。A组肌肉注射（i.m.）氮哌酮（Stresnil，40mg/ml注射液；Elanco动物保健公司），剂量为2mg/kg体重（b.w.）。B组鼻内给予2mg/kg体重的氮哌酮。C组鼻内给予4mg/kg体重的氮哌酮。D组鼻内给予1ml生理盐水，作为对照组。试验包括对特定刺激（用金属棒钝击围栏的金属边缘）的反应、流涎程度、活动水平、体温和血清氮哌酮浓度。我们发现，为了诱导出与标准给药方法（即2mg/kg体重肌肉注射）相当的足够镇静水平，需要鼻内给予4mg/kg体重的氮哌酮。
