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心脏衰老:派遣衔接蛋白增援。

Cardiac aging: Send in the vinculin reinforcements.

机构信息

San Antonio Cardiovascular Proteomics Center and Mississippi Center for Heart Research, Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, USA.

San Antonio Cardiovascular Proteomics Center and Mississippi Center for Heart Research, Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, USA. Research Service, G. V. (Sonny) Montgomery Veterans Affairs Medical Center, Jackson, MS 39216, USA.

出版信息

Sci Transl Med. 2015 Jun 17;7(292):292fs26. doi: 10.1126/scitranslmed.aab3391.

DOI:10.1126/scitranslmed.aab3391
PMID:26084802
Abstract

Integration of multiple analytical approaches across three species—fly, rat, and nonhuman primate—reveals additional roles for vinculin in cytoskeletal aging and cardiovascular disease (Kaushik et al., this issue).

摘要

整合三种物种(果蝇、大鼠和非人灵长类动物)的多种分析方法揭示了衔接蛋白在细胞骨架衰老和心血管疾病中的额外作用(Kaushik 等人,本期)。

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Cardiac aging: Send in the vinculin reinforcements.心脏衰老:派遣衔接蛋白增援。
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Front Cell Dev Biol. 2022 Mar 8;10:783724. doi: 10.3389/fcell.2022.783724. eCollection 2022.
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Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization.纽蛋白亚型的差异脂质结合促进近似等效的二聚化。
Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):9539-44. doi: 10.1073/pnas.1600702113. Epub 2016 Aug 8.
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Mechanisms and Functions of Vinculin Interactions with Phospholipids at Cell Adhesion Sites.纽蛋白在细胞黏附位点与磷脂相互作用的机制及功能
J Biol Chem. 2016 Feb 5;291(6):2548-55. doi: 10.1074/jbc.R115.686493. Epub 2016 Jan 4.