Izard Tina, Brown David T
From the Cell Adhesion Laboratory, Department of Cancer Biology and Department of Immunology and Microbial Sciences, The Scripps Research Institute, Jupiter, Florida 33458 and
the Department of Biochemistry, University of Mississippi Medical Center, Jackson, Mississippi 39216.
J Biol Chem. 2016 Feb 5;291(6):2548-55. doi: 10.1074/jbc.R115.686493. Epub 2016 Jan 4.
The cytoskeletal protein vinculin is a major regulator of cell adhesion and attaches to the cell surface by binding to specific phospholipids. Structural, biochemical, and biological studies provided much insight into how vinculin binds to membranes, what components it recognizes, and how lipid binding is regulated. Here we discuss the roles and mechanisms of phospholipids in regulating the structure and function of vinculin and of its muscle-specific metavinculin splice variant. A full appreciation of these processes is necessary for understanding how vinculin regulates cell motility, migration, and wound healing, and for understanding of its role in cancer and cardiovascular diseases.
细胞骨架蛋白纽蛋白是细胞黏附的主要调节因子，通过与特定磷脂结合而附着于细胞表面。结构、生化和生物学研究为纽蛋白如何与膜结合、识别哪些成分以及脂质结合如何受到调控提供了诸多见解。在此，我们讨论磷脂在调节纽蛋白及其肌肉特异性剪接变体间线蛋白的结构和功能方面的作用及机制。充分了解这些过程对于理解纽蛋白如何调节细胞运动、迁移和伤口愈合，以及其在癌症和心血管疾病中的作用至关重要。
