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[银屑病关节炎的药物治疗。有限证据背景下的治疗建议]

[Pharmacotherapy of psoriatic arthritis. Treatment recommendations against the background of limited evidence].

作者信息

Köhm M, Behrens F

机构信息

Abteilung Rheumatologie, Universitätsklinikum der Goethe-Universität Frankfurt/Main, Theodor-Stern-Kai 7, 60590, Frankfurt, Deutschland.

出版信息

Z Rheumatol. 2015 Jun;74(5):398-405. doi: 10.1007/s00393-014-1530-9.

Abstract

International treatment recommendations for assisting the choice of pharmaceutical treatment of psoriatic arthritis are currently available in two different versions. While the group for research and assessment of psoriasis and psoriatic arthritis (GRAPPA) recommendations mainly focus on both the description of treatment options for the different phenotypes of psoriatic arthritis and the listing of evidence grades, the European League against Rheumatism (EULAR) recommendations try to implement the knowledge about drugs into an algorithm for the different treatment steps. However, the presentation of a treatment algorithm suggests comparable evidence levels for the individual treatment steps, which is at present not the case for psoriatic arthritis. This should be borne in mind for each individual treatment option and treatment step when using a predetermined therapy algorithm and in view of the heterogeneous study results (or no study results available). Both recommendations are currently being revised and will allow the latest evidence trends to be included in the updated version.

摘要

目前有两个不同版本的国际治疗推荐,可辅助选择银屑病关节炎的药物治疗。银屑病和银屑病关节炎研究与评估小组(GRAPPA)的推荐主要侧重于描述银屑病关节炎不同表型的治疗选择以及证据等级列表,而欧洲抗风湿病联盟(EULAR)的推荐则试图将药物知识纳入针对不同治疗步骤的算法中。然而,治疗算法的呈现表明各个治疗步骤具有可比的证据水平,而目前银屑病关节炎并非如此。在使用预定的治疗算法时,鉴于研究结果的异质性(或无可用研究结果),对于每个单独的治疗选择和治疗步骤都应牢记这一点。目前这两个推荐都在修订,更新版本将纳入最新的证据趋势。

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