Hochstein Rebecca, Bollschweiler Daniel, Engelhardt Harald, Lawrence C Martin, Young Mark
Department of Microbiology and Immunology, Montana State University, Bozeman, Montana, USA.
Department of Molecular Structural Biology, Max-Planck-Institute for Biochemistry, Martinsried, Germany.
J Virol. 2015 Sep;89(18):9146-9. doi: 10.1128/JVI.00612-15. Epub 2015 Jun 17.
Viruses of Archaea continue to surprise us. Archaeal viruses have revealed new morphologies, protein folds, and gene content. This is especially true for large spindle viruses, which infect only Archaea. We present a comparison of particle morphologies, major coat protein structures, and gene content among the five characterized large spindle viruses to elucidate defining characteristics. Structural similarities and a core set of genes support the grouping of the large spindle viruses into a new superfamily.
古菌病毒不断给我们带来惊喜。古菌病毒展现出了新的形态、蛋白质折叠方式和基因组成。对于仅感染古菌的大型纺锤体病毒来说尤其如此。我们对五种已鉴定的大型纺锤体病毒的颗粒形态、主要衣壳蛋白结构和基因组成进行了比较,以阐明其决定性特征。结构上的相似性和一组核心基因支持将大型纺锤体病毒归为一个新的超家族。