Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA; Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA; Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA; NYU-ECNU Institute of Brain and Cognitive Science, New York University Shanghai, Shanghai 200122, China.
Neuron. 2015 Jun 17;86(6):1491-503. doi: 10.1016/j.neuron.2015.05.042.
To study rapid sensorimotor remapping, we developed a method to train rats in a behavior in which subjects are cued, on each trial, to apply a sensorimotor association to orient either toward a visual target ("Pro") or away from it, toward its reverse ("Anti"). Multiple behavioral asymmetries suggested that Anti behavior is cognitively demanding while Pro is easier to learn and perform. This is consistent with a prominent hypothesis in the primate literature that Anti requires prefrontal cortex (PFC), whereas Pro could be mediated by midbrain superior colliculus (SC). Pharmacological inactivation of rat medial PFC supported its expected role in Anti. Remarkably, bilateral SC inactivation substantially impaired Anti while leaving Pro essentially intact. Moreover, SC inactivation eliminated the performance cost of switching from Anti to Pro tasks. Our results establish a rodent model of single-trial sensorimotor remapping and suggest a critical role for SC in the cognitively demanding Anti task.
为了研究快速感觉运动重映射，我们开发了一种方法来训练大鼠进行一种行为，在每次试验中，大鼠会被提示将一种感觉运动联想应用于朝向或远离视觉目标（“Pro”）的方向，朝向其相反方向（“Anti”）。多项行为不对称性表明，Anti 行为认知要求高，而 Pro 则更容易学习和执行。这与灵长类动物文献中的一个主要假设一致，即 Anti 需要前额叶皮层（PFC），而 Pro 可能由中脑上丘（SC）介导。对大鼠内侧 PFC 的药理学失活支持了它在 Anti 中的预期作用。值得注意的是，双侧 SC 的失活显著损害了 Anti，而基本保留了 Pro。此外，SC 的失活消除了从 Anti 任务切换到 Pro 任务的表现成本。我们的结果建立了一种单试感觉运动重映射的啮齿动物模型，并表明 SC 在认知要求高的 Anti 任务中具有关键作用。
