Chemical Process Engineering, RWTH Aachen University, Turmstraße 46, 52064 Aachen, Germany.
Lab Chip. 2015 Aug 7;15(15):3132-7. doi: 10.1039/c5lc00428d.
We describe a novel membrane based gas-liquid-contacting device with increased mass transport and reduced pressure loss by combining a membrane with a staggered herringbone static mixer. Herringbone structures are imposed on the microfluidic channel geometry via soft lithography, acting as mixers which introduce secondary flows at the membrane interface. Such flows include Dean vortices and Taylor flows generating effective mixing while improving mass transport and preventing concentration polarization in microfluidic channels. Furthermore, our static herringbone mixer membranes effectively reduce pressure losses leading to devices with enhanced transfer properties for microfluidic gas-liquid contact. We investigate the red blood cell distribution to tailor our devices towards miniaturised extracorporeal membrane oxygenation and improved comfort of patients with lung insufficiencies.
我们描述了一种新颖的基于膜的气-液接触装置，通过将膜与交错的人字形静态混合器相结合，增加了传质并降低了压力损失。人字结构通过软光刻施加于微流道几何形状上，作为在膜界面处引入二次流的混合器。这些流动包括Dean 涡和 Taylor 流，在改善微流道中的传质和防止浓度极化的同时，产生有效的混合。此外，我们的静态人字形混合器膜有效地降低了压力损失，从而使微流气-液接触装置具有增强的传递性能。我们研究了红细胞的分布，以针对微型体外膜肺氧合和改善肺功能不全患者的舒适度来定制我们的设备。
