National Institute of Standards and Technology, Biochemical Science Division, Gaithersburg, MD, USA.
Lab Chip. 2012 Aug 7;12(15):2634-7. doi: 10.1039/c2lc40356k. Epub 2012 Jun 15.
We developed a computational model and theoretical framework to investigate the geometrical optimization of particle-surface interactions in a herringbone micromixer. The enhancement of biomolecule- and particle-surface interactions in microfluidic devices through mixing and streamline disruption holds promise for a variety of applications. This analysis provides guidelines for optimizing the frequency and specific location of surface interactions based on the flow pattern and relative hydraulic resistance between a groove and the effective channel. The channel bottom, i.e., channel surface between grooves, was identified as the dominant location for surface contact. In addition, geometries that decrease the groove-to-channel hydraulic resistance improve contact with the channel top. Thus, herringbone mixers appear useful for a variety of surface-interaction applications, yet they have largely not been employed in an optimized fashion.
我们开发了一种计算模型和理论框架，用于研究人字形微混合器中颗粒-表面相互作用的几何优化。通过混合和流线破坏来增强微流控设备中生物分子和颗粒-表面相互作用，为各种应用带来了希望。该分析为基于流动模式和凹槽与有效通道之间的相对水力阻力，优化表面相互作用的频率和特定位置提供了指导。通道底部，即凹槽之间的通道表面，被确定为表面接触的主要位置。此外，降低凹槽到通道水力阻力的几何形状可以改善与通道顶部的接触。因此，人字形混合器似乎非常适合各种表面相互作用的应用，但它们在优化方面的应用还没有得到广泛应用。
