Coret F, Vílchez J J, Enguídanos M J, López-Arlandis J, Fernández-Izquierdo S
Rev Clin Esp. 1989 Oct;185(5):231-4.
The polyacrylamide gel electrophoresis of spinal fluid from 488 patients suffering neurological diseases and from a control group are reviewed. One hundred and eleven cases (22.7%) showed oligoclonal bands (OB). The highest percentage of OB appeared in the group of patients with definite multiple sclerosis (84%), followed by those with probable multiple sclerosis (46%) and inflammatory infectious diseases (43%); the group of patients with a possible multiple sclerosis (7%), vascular malignancies (11%) and other diseases (4%) showed a lower incidence of OBs. No OBs were found in groups of patients with degenerative diseases, dementia or the control group. These results confirm the great usefulness of this test to support the diagnosis of multiple sclerosis, although it also shows that it is not a specific test so it should always be evaluated within a clinical context.
回顾了488例神经系统疾病患者和一个对照组的脑脊液聚丙烯酰胺凝胶电泳情况。111例（22.7%）出现寡克隆带（OB）。OB出现比例最高的是确诊多发性硬化症患者组（84%），其次是可能患有多发性硬化症的患者组（46%）和炎症性传染病患者组（43%）；可能患有多发性硬化症的患者组（7%）、血管恶性肿瘤患者组（11%）和其他疾病患者组（4%）的OB发生率较低。在退行性疾病、痴呆患者组或对照组中未发现OB。这些结果证实了该检测对支持多发性硬化症诊断的巨大作用，尽管也表明它不是一项特异性检测，因此应始终在临床背景下进行评估。
