Lee Ju Ah, Ko Mi Mi, Lee Jungsup, Kang Byoung-Kab, Alraek Terje, Birch Stephen, Lee Myeong Soo
Medical Research Division, Brain Disease Research Center, Korea Institute of Oriental Medicine, 1672 Yuseongdae-ro, Yuseong-gu, Daejeon 305-811, Republic of Korea.
Korean National Rehabilitation Center, Seoul, Republic of Korea.
Evid Based Complement Alternat Med. 2015;2015:869894. doi: 10.1155/2015/869894. Epub 2015 May 18.
The aim of this study is to extract indicators that are associated with the heat/nonheat and excess/deficiency patterns in stroke pattern identification through the large-scale analysis of clinical data. Two experts, who had more than three years of clinical experience with stroke, independently performed the pattern identification. We analyzed indicators of clinical data with two doctors' concurrent diagnoses on the patient's pattern identification. To verify heat/nonheat and excess/deficiency patterns, which are the basic elements of pattern identification, we grouped 960 patients diagnosed as the fire-heat pattern, the Yin deficiency pattern, and the Qi deficiency pattern in to two groups, the heat/nonheat group and the excess/deficiency group. We then extracted significant indicators using univariate and multivariate analysis. As a result of the comparison of 65 indicators, we were able to extract 10 indicators for the heat pattern, 6 for the nonheat pattern, 9 for the excess pattern, and 10 for the deficiency pattern. Extracted indicators in this study can be used for pattern identification in the context of stroke. These are positive indicators from large-scale clinical studies and are greatly expected to be crucial discriminant indicators in individual pattern identification henceforth.
本研究的目的是通过对临床数据的大规模分析,提取与中风辨证中热证/非热证及实证/虚证相关的指标。两位具有三年以上中风临床经验的专家独立进行辨证。我们分析了两位医生对患者辨证的同时诊断的临床数据指标。为了验证作为辨证基本要素的热证/非热证及实证/虚证,我们将960例被诊断为火热证、阴虚证和气虚证的患者分为两组,即热证/非热证组和实证/虚证组。然后我们使用单变量和多变量分析提取显著指标。通过对65项指标的比较,我们能够提取出热证指标10项、非热证指标6项、实证指标9项和虚证指标10项。本研究中提取的指标可用于中风背景下的辨证。这些是来自大规模临床研究的阳性指标,有望在今后的个体辨证中成为关键的判别指标。