Zhang Li, Lu Yunjie, Ge Yuzheng, Shi Yun, Wu Xing, Xu Qinghua, Li Xiaoping, Lu Ling, Zhang Feng, Yao Guozhong
Liyang People's Hospital, Liyang 213300, China.
Translational Medicine Research Center of Jiangning Hospital and Liver Transplantation Center of First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.
J Immunol Res. 2015;2015:279849. doi: 10.1155/2015/279849. Epub 2015 May 18.
The association between Interleukin-23R gene polymorphism and Crohn's disease (CD) in Caucasians is still controversial. Thus, a meta-analysis was performed to evaluate the correlation between this gene variant and CD risk. We retrieved the available data from EMBASE and PUBMED until May 1, 2014, and evaluated the effect of rs7517847 in Caucasians. The significant associations were confirmed between rs7517847 and CD risk in dominant models (TT/TG versus GG: OR = 1.652, 95% CI 1.277, 2.137), allelic model (T allele versus G allele: OR = 1.327, 95% CI 1.198, 1.469), homozygote comparison (TT versus GG: OR = 1.890, 95% CI 1.465, 2.437), heterozygote comparison (TG versus GG: OR = 1.509, 95% CI 1.161, 1.960), and recessive model (TT versus
TG/GG: OR = 1.409, 95% CI 1.279, 1.552). In conclusion, this meta-analysis demonstrates that rs7517847 is associated with the risk of CD in Caucasians. These findings show that IL-23R genes confer susceptibility to CD in the Caucasians.
白细胞介素-23受体（Interleukin-23R）基因多态性与白种人克罗恩病（CD）之间的关联仍存在争议。因此，进行了一项荟萃分析以评估该基因变异与CD风险之间的相关性。我们检索了截至2014年5月1日来自EMBASE和PUBMED的可用数据，并评估了白种人中rs7517847的作用。在显性模型（TT/TG与GG相比：比值比（OR）=1.652，95%置信区间（CI）1.277，2.137）、等位基因模型（T等位基因与G等位基因相比：OR = 1.327，95%CI 1.198，1.469）、纯合子比较（TT与GG相比：OR = 1.890，95%CI 1.465，2.437）、杂合子比较（TG与GG相比：OR = 1.509，95%CI 1.161，1.960）以及隐性模型（TT与TG/GG相比：OR = 1.409，95%CI 1.279，1.552）中，均证实rs7517847与CD风险存在显著关联。总之，这项荟萃分析表明rs7517847与白种人患CD的风险相关。这些发现表明白细胞介素-23受体基因使白种人易患克罗恩病。
