Department of Gastroenterology, Keio University School of Medicine, 160-8582 Tokyo, Japan.
Hubrecht Institute, KNAW and University Medical Centre Utrecht, Uppsalalaan 8, 3584CT Utrecht, the Netherlands.
Cell. 2015 Jun 18;161(7):1700-1700.e1. doi: 10.1016/j.cell.2015.06.028.
Tissue stem cells require unique niche microenvironments. In the presence of specific combinations of niche factors, mouse and human epithelial tissues from stomach, small intestine, colon, pancreas duct, and liver bile duct efficiently form stereotypic organoids. The platform of epitheloid organoids can also be employed for in vitro generation of digestive tissue from human pluripotent stem cells. Organoids hold great promise for basic and translational research.
组织干细胞需要独特的生态位微环境。在特定组合的生态位因子存在的情况下，从小鼠和人胃、小肠、结肠、胰腺导管和肝胆管中分离出的上皮组织能够有效地形成具有典型特征的类器官。类器官的平台也可用于从人类多能干细胞体外生成消化组织。类器官在基础和转化研究中具有巨大的应用前景。
