Liu Bin, Pang Bo, Liu Huajie, Arakawa Yoshiki, Zhang Rui, Feng Bin, Zhong Peng, Murata Daiki, Fan Haitao, Xin Tao, Zhao Guangyu, Liu Wei, Guo Hua, Luan Liming, Xu Shangchen, Miyamoto Susumu, Pang Qi
Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, PR China; Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto 606-8527, Japan.
Department of Neurosurgery, Shandong University Graduate School of Medicine, Jinan 250012, PR China.
Pathol Res Pract. 2015 Aug;211(8):596-600. doi: 10.1016/j.prp.2015.05.004. Epub 2015 May 28.
The aim of this study was to explore the difference in high mobility group A1 (HMGA1) expression and isocitrate dehydrogenase (IDH) 1 R132H point mutation in initial and recurrent glioblastoma multiforme (GBM), and to further identify whether the expression of HMGA1 has a role in the malignant progression of GBM. Paired initial and recurrent GBM specimens from the same patient were evaluated using immunohistochemical analysis. The association between HMGA1 expression and progression-free survival time (PFST) was analyzed. Three patients were confirmed with IDH-1 R132H mutations in both initial and recurrent groups (3/25, 12%). There was a significant difference in HMGA1 expression between initial and recurrent GBM (P=0.002), and patients with tumors expressing HMGA1 at higher level had a significantly shorter PFST (7.3 months versus 11.1months; P=0.044). Our study indicates that recurrent GBM express HMGA1 at a higher level and that HMGA1 overexpressoin is associated with shorter PFST in patients with GBM. These findings suggest that HMGA1 potentially plays an important role in the treatment of GBM.
本研究旨在探讨初发和复发的多形性胶质母细胞瘤（GBM）中高迁移率族蛋白A1（HMGA1）表达及异柠檬酸脱氢酶（IDH）1 R132H点突变的差异，并进一步确定HMGA1的表达是否在GBM的恶性进展中发挥作用。采用免疫组化分析对来自同一患者的配对初发和复发GBM标本进行评估。分析HMGA1表达与无进展生存时间（PFST）之间的关联。初发组和复发组均有3例患者确诊存在IDH-1 R132H突变（3/25，12%）。初发和复发GBM的HMGA1表达存在显著差异（P=0.002），HMGA1表达水平较高的肿瘤患者的PFST显著缩短（7.3个月对11.1个月；P=0.044）。我们的研究表明，复发GBM中HMGA1表达水平较高，且HMGA1过表达与GBM患者较短的PFST相关。这些发现提示HMGA1可能在GBM的治疗中发挥重要作用。
