miSEA：微小RNA集富集分析。

miSEA: microRNA set enrichment analysis.

作者信息

Çorapçıoğlu M Erdem, Oğul Hasan

机构信息

Department of Computer Engineering, Baskent University, Ankara, Turkey; Department of Technology and Information Management, Baskent University, Ankara, Turkey.

Department of Computer Engineering, Baskent University, Ankara, Turkey.

出版信息

Biosystems. 2015 Aug;134:37-42. doi: 10.1016/j.biosystems.2015.05.004. Epub 2015 Jun 17.

DOI:10.1016/j.biosystems.2015.05.004

PMID:26093049

Abstract

UNLABELLED

We introduce a novel web-based tool, miSEA, for evaluating the enrichment of relevant microRNA sets from microarray and miRNA-Seq experiments on paired samples, e.g. control vs.

TREATMENT

In addition to a group of previously annotated microRNA sets embedded in the system, this tool enables users to import new microRNA sets obtained from their own research. miSEA allows users to select from a large variety of microRNA grouping categories, such as family classification, disease association, common regulation, and genome coordinates, based on their requirements. miSEA therefore provides a knowledge-driven representation scheme for microRNA experiments. The usability of this platform was discerned with a cancer type-classification task performed on a set of real microRNA expression profiling experiments. The miSEA web server is available at http://www.baskent.edu.tr/∼hogul/misea.

摘要

未标注

我们推出了一种新型的基于网络的工具miSEA，用于评估在配对样本（如对照与治疗）的微阵列和miRNA测序实验中相关miRNA集的富集情况。

治疗

除了系统中嵌入的一组先前注释的miRNA集外，该工具还允许用户导入从自己的研究中获得的新miRNA集。miSEA允许用户根据自己的需求从多种miRNA分组类别中进行选择，例如家族分类、疾病关联、共同调控和基因组坐标。因此，miSEA为miRNA实验提供了一种知识驱动的表示方案。通过对一组真实的miRNA表达谱实验执行癌症类型分类任务，验证了该平台的可用性。miSEA网络服务器可在http://www.baskent.edu.tr/∼hogul/misea上获取。