Huang Zhiguang, Cai Ling, Tu Benjamin P
Department of Biochemistry, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
Children's Medical Center Research Institute, UT Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA.
Curr Opin Cell Biol. 2015 Jun;34:69-74. doi: 10.1016/j.ceb.2015.05.004. Epub 2015 Jun 19.
Organisms must be able to rapidly alter gene expression in response to changes in their nutrient environment. This review summarizes evidence that epigenetic modifications of chromatin depend on particular metabolites of intermediary metabolism, enabling the facile regulation of gene expression in tune with metabolic state. Nutritional or dietary control of chromatin is an often-overlooked, yet fundamental regulatory mechanism directly linked to human physiology. Nutrient-sensitive epigenetic marks are dynamic, suggesting rapid turnover, and may have functions beyond the regulation of gene transcription, including pH regulation and as carbon sources in cancer cells.
生物体必须能够根据其营养环境的变化迅速改变基因表达。本综述总结了证据，表明染色质的表观遗传修饰依赖于中间代谢的特定代谢产物，从而能够根据代谢状态轻松调节基因表达。染色质的营养或饮食控制是一种经常被忽视但与人类生理学直接相关的基本调节机制。营养敏感的表观遗传标记是动态的，表明其周转迅速，并且可能具有基因转录调节之外的功能，包括pH调节以及作为癌细胞的碳源。
