T淋巴细胞母细胞白血病/淋巴瘤中的BCR-PDGFRA融合
BCR-PDGFRA fusion in a T lymphoblastic leukemia/lymphoma.
作者信息
Yigit Nuri, Wu William W, Subramaniyam Shivakumar, Mathew Susan, Geyer Julia T
机构信息
Department of Pathology and Laboratory Medicine, Weill Cornell Medical College/NewYork-Presbyterian Hospital, New York, NY, USA; Department of Pathology, Gulhane Military Medical Academy and School of Medicine, Ankara, Turkey.
Department of Pathology and Laboratory Medicine, Weill Cornell Medical College/NewYork-Presbyterian Hospital, New York, NY, USA.
出版信息
Cancer Genet. 2015 Jul-Aug;208(7-8):404-7. doi: 10.1016/j.cancergen.2015.04.007. Epub 2015 Apr 28.
The BCR-PDGFRA fusion is a very rare event. To date, only eight cases of hematolymphoid neoplasms with the BCR-PDGFRA fusion gene have been reported. All cases except one had eosinophilia. We present the first case of T acute lymphoblastic leukemia with a t(4;22)(q12;q11.2) involving the BCR and PDGFRA genes, without associated eosinophilia. Radiology showed splenomegaly and extensive lymph node involvement. The patient rapidly achieved complete remission with treatment protocol for Philadelphia chromosome-negative acute lymphoblastic leukemia.
BCR-PDGFRA融合是一种非常罕见的情况。迄今为止，仅报道了8例伴有BCR-PDGFRA融合基因的血液淋巴系统肿瘤。除1例之外，所有病例均有嗜酸性粒细胞增多。我们报告首例t(4;22)(q12;q11.2)累及BCR和PDGFRA基因且无相关嗜酸性粒细胞增多的T急性淋巴细胞白血病病例。放射学检查显示脾肿大和广泛的淋巴结受累。该患者采用费城染色体阴性急性淋巴细胞白血病治疗方案后迅速获得完全缓解。
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