用于颞下颌关节发育和疾病的小鼠遗传模型。
Mouse genetic models for temporomandibular joint development and disorders.
作者信息
Suzuki A, Iwata J
机构信息
Department of Diagnostic & Biomedical Sciences, School of Dentistry, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA.
Center for Craniofacial Research, UTHealth, Houston, TX, USA.
出版信息
Oral Dis. 2016 Jan;22(1):33-8. doi: 10.1111/odi.12353. Epub 2015 Jul 2.
Abstract
The temporomandibular joint (TMJ) is a synovial joint essential for hinge and sliding movements of the mammalian jaw. Temporomandibular joint disorders (TMD) are dysregulations of the muscles or the TMJ in structure, function, and physiology, and result in pain, limited mandibular mobility, and TMJ noise and clicking. Although approximately 40-70% adults in the USA have at least one sign of TMD, the etiology of TMD remains largely unknown. Here, we highlight recent advances in our understanding of TMD in mouse models.
摘要
颞下颌关节（TMJ）是一种滑膜关节，对哺乳动物颌骨的铰链和滑动运动至关重要。颞下颌关节紊乱病（TMD）是指肌肉或颞下颌关节在结构、功能和生理方面的失调，会导致疼痛、下颌活动受限以及颞下颌关节出现杂音和弹响。尽管美国约40%-70%的成年人至少有一项颞下颌关节紊乱病的症状，但其病因在很大程度上仍不清楚。在此，我们重点介绍在小鼠模型中对颞下颌关节紊乱病的最新认识进展。
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