[Regularities of formation in a general population of serum antibodies to previously circulated influenza A viruses].

The spectrum of antibody production against hemagglutinin of all known influenza A virus serotypes after influenza A (H3N2) infection in persons of all age groups (from 1 month to 72 years) was analysed to investigated the regularities of accumulation of antibodies against influenza A viruses gone out of circulation. For the same purpose, a long-term (many years) longitudinal analysis of serum anti-HA antibody levels against "old" influenza A (HSW1N1), A (H0N1), A (H1N1), A (H2N2), and A (H3N2) viruses was carried out in children and adults of various age groups in 6 cities of different geographical regions of the country. Based on the results of the study, the concept of the "original antigenic sin" is analysed critically, and a new original concept on the regularities of antibody genesis against previously prevalent influenza A viruses and the factors affecting this process has been formulated.