Mendiola J, Melgarejo M, Moñino-García M, Cutillas-Tolín A, Noguera-Velasco J A, Torres-Cantero A M
Division of Preventive Medicine and Public Health, Department of Health and Social Sciences, University of Murcia School of Medicine, IMIB-Arrixaca., Espinardo (Murcia), Spain.
Department of Laboratory Medicine, "Virgen de la Arrixaca" University Hospital, El Palmar (Murcia), Spain.
Andrology. 2015 Jul;3(4):672-6. doi: 10.1111/andr.12059. Epub 2015 Jun 20.
Experimental studies have shown that anogenital distance (AGD) at birth reflects androgen concentrations during prenatal development and predicts adult AGD. In male rodents, shortened AGD is associated with compromised reproductive function. The aim of this study was to examine associations between AGD measures and semen quality in male partners of subfertile couples. All men were attending an infertility service and provided a semen sample and completed epidemiological questionnaires on lifestyle and general health. Two variants of AGD [from the anus to the posterior base of the scrotum (AGDAS) and to the cephalad insertion of the penis (AGDAP)] were assessed in 91 men. Semen parameters (semen volume, sperm concentration, total sperm counts, motility, and morphology) were determined following WHO guidelines. Associations between AGD measures and semen quality were tested using multiple regression analyses controlling for appropriate covariates. Significant positive associations between AGDAS measures and sperm concentration, total sperm count, and total sperm motile count were detected (p-values < 0.05). This study represents the first analysis of AGD in potential infertile European men showing an association between perineal length and semen parameters. However, it is still uncertain the utility to clinical practice, therefore further studies are warranted to confirm and extent these findings.
实验研究表明，出生时的肛殖距（AGD）反映了产前发育期间的雄激素浓度，并可预测成年后的AGD。在雄性啮齿动物中，AGD缩短与生殖功能受损有关。本研究的目的是检查不育夫妇男性伴侣的AGD测量值与精液质量之间的关联。所有男性均前往不孕不育门诊，提供了精液样本，并完成了关于生活方式和总体健康状况的流行病学问卷调查。对91名男性评估了两种AGD变体[从肛门到阴囊后基部（AGDAS）以及到阴茎头端插入处（AGDAP）]。按照世界卫生组织指南测定精液参数（精液量、精子浓度、总精子数、活力和形态）。使用控制适当协变量的多元回归分析来检验AGD测量值与精液质量之间的关联。检测到AGDAS测量值与精子浓度、总精子数和总精子活动数之间存在显著正相关（p值<0.05）。本研究首次对潜在不育的欧洲男性进行了AGD分析，显示会阴长度与精液参数之间存在关联。然而，其在临床实践中的效用仍不确定，因此有必要进一步研究以证实并扩展这些发现。
