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伴有口腔表现的固定性药疹。

Fixed drug eruptions with intraoral presentation.

作者信息

Srivastava Rahul, Bihari Manorama, Bhuvan Jyoti, Saad Ahmed

机构信息

Department of Oral Medicine and Radiology, Rama Dental College Hospital and Research Centre, Kanpur, India.

Department of Physiology, CM Medical College, Durg, Chattisgarh, India.

出版信息

Indian J Dent. 2015 Apr-Jun;6(2):103-6. doi: 10.4103/0975-962X.154376.

DOI:10.4103/0975-962X.154376
PMID:26097341
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4455151/
Abstract

Fixed-drug eruption (FDE) is an unusual and rare adverse drug reaction. This type of reaction is actually a delayed type of hypersensitivity reaction that occurs as lesions recurring at the same skin site due to repeated intake of an offending drug. Here is a case report of a 58-year-old male patient who developed intraoral FDEs after ingestion of the first dose of ornidazole.

摘要

固定性药疹（FDE）是一种不常见且罕见的药物不良反应。这种反应实际上是一种迟发型超敏反应，因反复摄入致病药物而在同一皮肤部位出现皮疹复发。以下是一例58岁男性患者的病例报告，该患者在服用第一剂奥硝唑后出现口腔内固定性药疹。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd98/4455151/c3208c39a2cd/IJDENT-6-103-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd98/4455151/3b3116e6b3f5/IJDENT-6-103-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd98/4455151/e8c1c0c0f816/IJDENT-6-103-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd98/4455151/c3208c39a2cd/IJDENT-6-103-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd98/4455151/3b3116e6b3f5/IJDENT-6-103-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd98/4455151/e8c1c0c0f816/IJDENT-6-103-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd98/4455151/c3208c39a2cd/IJDENT-6-103-g003.jpg

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本文引用的文献

1
Etiology and pathogenesis of adverse drug reactions.药物不良反应的病因及发病机制。
Chem Immunol Allergy. 2012;97:32-46. doi: 10.1159/000335614. Epub 2012 May 3.
2
Drug allergy.药物过敏。
Allergy Asthma Clin Immunol. 2011 Nov 10;7 Suppl 1(Suppl 1):S10. doi: 10.1186/1710-1492-7-S1-S10.
3
Multiple fixed drug eruption caused by ornidazole.奥硝唑引起的多发性固定性药疹。
Ivermectin-induced fixed drug eruption in an elderly Cameroonian: a case report.
一名喀麦隆老年患者因伊维菌素引发的固定性药疹：病例报告。
J Med Case Rep. 2018 Sep 11;12(1):254. doi: 10.1186/s13256-018-1801-1.
Dermatitis. 2010 Nov-Dec;21(6):330-3.
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Fixed drug eruption with ornidazole having cross-sensitivity to secnidazole but not to other nitro-imidazole compounds: a case report.奥硝唑所致固定性药疹对塞克硝唑存在交叉敏感性，但对其他硝基咪唑类化合物无交叉敏感性：1例病例报告
Br J Clin Pharmacol. 2010 Jun;69(6):703-4. doi: 10.1111/j.1365-2125.2010.03651.x.
5
Desensitization to co-trimoxazole in a patient with fixed drug eruption.一名固定性药疹患者对复方新诺明的脱敏治疗
J Investig Allergol Clin Immunol. 2008;18(4):309-11.
6
A comparison of metronidazole and single-dose ornidazole for the treatment of dientamoebiasis.甲硝唑与单剂量奥硝唑治疗人芽囊原虫病的比较。
Clin Microbiol Infect. 2008 Jun;14(6):601-4. doi: 10.1111/j.1469-0691.2008.02002.x. Epub 2008 Apr 5.
7
Current opinion on drug-induced oral reactions: a comprehensive review.药物性口腔反应的当前观点：全面综述
J Contemp Dent Pract. 2008 Mar 1;9(3):1-15.
8
Oral fixed drug eruption due to fluconazole.氟康唑引起的口腔固定性药疹。
Indian J Dermatol Venereol Leprol. 2006 Sep-Oct;72(5):391. doi: 10.4103/0378-6323.27767.
9
Fixed drug eruption (FDE): changing scenario of incriminating drugs.固定性药疹（FDE）：致敏药物情况的变化
Int J Dermatol. 2006 Aug;45(8):897-908. doi: 10.1111/j.1365-4632.2006.02853.x.
10
Fixed drug eruption caused by ornidazole.奥硝唑引起的固定性药疹。
Contact Dermatitis. 2005 Nov;53(5):300-1. doi: 10.1111/j.0105-1873.2005.0654b.x.