Ngwasiri Calypse Asangbe, Abanda Martin Hongieh, Aminde Leopold Ndemnge
Bamendjou District Hospital, Bamendjou, West Region, Cameroon.
Clinical Research Education, Networking & Consultancy (CRENC), Douala, Cameroon.
J Med Case Rep. 2018 Sep 11;12(1):254. doi: 10.1186/s13256-018-1801-1.
Cutaneous adverse reactions to medications are extremely common and display characteristic clinical morphology. A fixed drug eruption is a cutaneous adverse drug reaction due to type IV or delayed cell-mediated hypersensitivity. Ivermectin, a broad-spectrum anti-parasitic compound, has been an essential component of public health campaigns targeting the control of two devastating neglected tropical diseases: onchocerciasis (river blindness) and lymphatic filariasis.
We report the case of a 75-year-old Cameroonian man of the Bamileke ancestry who developed multiple fixed drug eruptions a few hours following ivermectin intake that worsened with repeated drug consumption. Discontinuation of the drug, counselling, systemic steroids, and orally administered antihistamines were the treatment modalities employed. Marked regression of the lesions ensued with residual hyperpigmentation and dyschromia.
Keen observation on the part of physicians is mandatory during the administration of ivermectin for quick recognition and prevention of this adverse drug reaction.
药物引起的皮肤不良反应极为常见，并呈现出特征性的临床形态。固定性药疹是一种由IV型或迟发性细胞介导的超敏反应引起的皮肤药物不良反应。伊维菌素是一种广谱抗寄生虫化合物，一直是旨在控制两种严重被忽视的热带病——盘尾丝虫病（河盲症）和淋巴丝虫病的公共卫生运动的重要组成部分。
我们报告了一例75岁的喀麦隆男子，他具有巴米累克族血统，在服用伊维菌素几小时后出现多处固定性药疹，且随着药物的反复服用病情加重。停药、咨询、全身性类固醇和口服抗组胺药是所采用的治疗方式。随后皮损明显消退，留有色素沉着和色素异常。
在使用伊维菌素期间，医生必须敏锐观察，以便快速识别和预防这种药物不良反应。
