Schlegel A, Kron P, Dutkowski P
Department of Surgery and Transplantation, University Hospital Zürich, Raemistr. 100, 8091 Zurich, Switzerland.
Curr Transplant Rep. 2015;2(1):52-62. doi: 10.1007/s40472-014-0046-1.
Dynamic preservation strategies such as hypothermic machine perfusion are increasingly discussed to improve liver graft quality before transplantation. This review summarizes current knowledge of this perfusion technique for liver preservation. We discuss optimization of perfusion conditions and current strategies to assess graft quality during cold perfusion. Next, we provide an overview of possible pathways of protection from ischemia-reperfusion injury. Finally, we report on recent clinical applications of human hypothermic machine liver perfusion.
诸如低温机器灌注等动态保存策略在移植前改善肝移植质量方面的讨论日益增多。本综述总结了目前关于这种肝脏保存灌注技术的知识。我们讨论了灌注条件的优化以及在冷灌注期间评估移植物质量的当前策略。接下来，我们概述了预防缺血再灌注损伤的可能途径。最后，我们报告了人类低温机器肝脏灌注的近期临床应用情况。
