Foletti Alberto, Ledda Mario, Grimaldi Settimio, D'Emilia Enrico, Giuliani Livio, Liboff Abraham, Lisi Antonella
Institute of Translational Pharmacology, National Research Council - CNR , Rome , Italy .
Electromagn Biol Med. 2015;34(2):147-50. doi: 10.3109/15368378.2015.1036073.
Several years ago just before Christmas, in a small meeting room at the Institute of Pharmacology at the University of Rome, we had the opportunity to attend a meeting on "The role of QED in medicine" by Emilio Del Giudice and Giuliano Preparata. Before that meeting, we were more oriented towards a mechanistic view of Biochemistry and Medicine, believing that chemical reactions could only take place when a random collision between molecules with a gain in energy takes place. We envisioned water as just a solvent in which was possible to dissolve a solute. After we listened to Giuliano's and Emilio's speech on the "New physics of water", and on "The possible origin of coherence in cell, tissues and the interaction of very weak and low frequency magnetic fields with the ions, systems of the cell", we realized that living organisms are complex electrochemical systems which evolved in a relatively narrow range of well-defined environmental parameters. Environmental natural electro-magnetic fields are an ubiquitous factor in nature. If nature gave certain organisms the ability to receive information about the environment via invisible electromagnetic signals, then there must also the capability to discriminate between significant and meaningless ones. Bearing in mind that electromagnetic fields can be perceived by living organisms by means a resonance effect, we should not be amazed if they can be able to induce different biological effects. The work that we will present in memory of Emilio is based on the hypotheses that an aqueous system a chemical differentiation agent such as retinoic acid (RA) were electronically captured and transferred to the culture medium of Neuroblastoma Cell Line (LAN-5) and the proliferation rate was assessed to assess cell responses to the electromagnetic information transfer through the aqueous system. Like those enfolded in living organisms could play a synergic role in modulating biological functions, generating dissipative structures under appropriate patterns of electromagnetic signals providing basis for storing and retrieving biological activities. An external electro-magnetic stimulus from a source molecule can be stored, translated, and transferred by the aqueous systems to the biological target, selectively driving their endogenous activity and mimicking the effect of a source molecule.
几年前，就在圣诞节前夕，在罗马大学药理学研究所的一个小会议室里，我们有幸参加了由埃米利奥·德尔·朱迪切和朱利亚诺·普雷帕拉塔主持的关于“量子电动力学在医学中的作用”的会议。在那次会议之前，我们更倾向于生物化学和医学的机械论观点，认为化学反应只有在分子之间随机碰撞并获得能量时才会发生。我们把水仅仅看作是一种可以溶解溶质的溶剂。在我们听了朱利亚诺和埃米利奥关于“水的新物理学”以及“细胞、组织中相干性的可能起源以及极弱和低频磁场与细胞离子系统的相互作用”的演讲后，我们意识到生物体是复杂的电化学系统，它们在相对狭窄的明确定义的环境参数范围内进化。环境自然电磁场是自然界中无处不在的因素。如果大自然赋予某些生物体通过不可见电磁信号接收环境信息的能力，那么它们也必然有能力区分有意义和无意义的信号。考虑到生物体可以通过共振效应感知电磁场，那么它们能够产生不同的生物效应也就不足为奇了。我们将为纪念埃米利奥而展示的这项工作基于这样的假设：一种水性系统——一种化学分化剂，如视黄酸（RA）——被电子捕获并转移到神经母细胞瘤细胞系（LAN - 5）的培养基中，通过评估增殖率来评估细胞对通过水性系统进行的电磁信息传递的反应。就像生物体中包含的那些可能在调节生物功能方面发挥协同作用，在适当的电磁信号模式下产生耗散结构，为存储和检索生物活性提供基础。来自源分子的外部电磁刺激可以被水性系统存储、转化并转移到生物靶点，选择性地驱动其内源活性并模拟源分子的效果。
