Tarle Victoria, Ravasio Andrea, Hakim Vincent, Gov Nir S
Department of Chemical Physics, Weizmann Institute of Science, Rehovot 76100, Israel.
Integr Biol (Camb). 2015 Oct;7(10):1218-27. doi: 10.1039/c5ib00092k. Epub 2015 Jun 22.
Collective motion occurs in many biological processes, such as wound healing, tumor invasion and embryogenesis. Experiments of cell monolayer migration have revealed the spontaneous formation of finger-like instabilities, with leader cells at their tips. We present a particle-based model for collective cell migration, based on several elements that have been found experimentally to influence cellular movement. Inside the bulk we include velocity alignment interactions between neighboring cells. At the border contour of the layer we introduce the following additional forces: surface-elasticity restoring force, curvature-dependent positive feedback, and contractile acto-myosin cables. We find that the curvature-driven instability at the layer edge is necessary and sufficient for the formation of cellular fingers, which are in good agreement with experimental observations.
集体运动发生在许多生物过程中，如伤口愈合、肿瘤侵袭和胚胎发生。细胞单层迁移实验揭示了手指状不稳定性的自发形成，其顶端有引导细胞。我们提出了一种基于粒子的集体细胞迁移模型，该模型基于几个实验发现会影响细胞运动的因素。在主体内部，我们考虑了相邻细胞之间的速度对齐相互作用。在层的边界轮廓处，我们引入了以下附加力：表面弹性恢复力、曲率相关的正反馈和收缩性肌动蛋白-肌球蛋白束。我们发现，层边缘的曲率驱动不稳定性对于细胞手指的形成是必要且充分的，这与实验观察结果高度吻合。
