Tarle Victoria, Gauquelin Estelle, Vedula S R K, D'Alessandro Joseph, Lim C T, Ladoux Benoit, Gov Nir S
Department of Chemical Physics, Weizmann Institute of Science, Rehovot 76100, Israel.
Phys Biol. 2017 May 3;14(3):035001. doi: 10.1088/1478-3975/aa6591.
Monolayer expansion has generated great interest as a model system to study collective cell migration. During such an expansion the culture front often develops 'fingers', which we have recently modeled using a proposed feedback between the curvature of the monolayer's leading edge and the outward motility of the edge cells. We show that this model is able to explain the puzzling observed increase of collective cellular migration speed of a monolayer expanding into thin stripes, as well as describe the behavior within different confining geometries that were recently observed in experiments. These comparisons give support to the model and emphasize the role played by the edge cells and the edge shape during collective cell motion.
单层扩展作为一种研究集体细胞迁移的模型系统引起了极大的兴趣。在这种扩展过程中，培养前沿常常会形成“指状物”，我们最近利用单层前沿曲率与边缘细胞向外运动性之间的一种假定反馈对其进行了建模。我们表明，该模型能够解释观察到的单层扩展成细条时集体细胞迁移速度令人困惑的增加现象，还能描述最近在实验中观察到的不同限制几何形状内的行为。这些比较为该模型提供了支持，并强调了边缘细胞和边缘形状在集体细胞运动过程中所起的作用。
