Zhang Bin, Tian Derun, Yu Chunshui, Li Meng, Zang Yufeng, Liu Yijun, Walter Martin
1] Department of Anatomy, Tianjin Medical University, Tianjin, China [2] Department of Psychiatry and Psychotherapy, University of Magdeburg, Magdeburg, Germany [3] Clinical Affective Neuroimaging Laboratory, University of Magdeburg, Magdeburg, Germany [4] Leibniz Institute for Neurobiology, Magdeburg, Germany.
Department of Anatomy, Tianjin Medical University, Tianjin, China.
Sci Rep. 2015 Jun 23;5:11563. doi: 10.1038/srep11563.
Obesity as a chronic disease is a major factor for insulin resistance and Type 2 diabetes, which has become a global health problem. In the present study, we used resting state functional MRI to investigate the amplitude of low frequency fluctuations of spontaneous signal during both hunger and satiety states in 20 lean and 20 obese males. We found that, before food intake, obese men had significantly greater baseline activity in the precuneus and lesser activity in dorsal anterior cingulate cortex (dACC) relative to lean subjects. Furthermore, after food intake, obese males had significantly lesser activity in dACC than lean males. We further found a significant positive correlation between precuneus activation and hunger ratings before food intake, while dACC activity was negatively correlated with plasma insulin levels before and after food intake. These results indicated that both precuneus and dACC may play an important role in eating behavior. While precuneus rather seemed to mediate subjective satiety, dACC levels rather reflected indirect measures of glucose utilization.
肥胖作为一种慢性疾病，是胰岛素抵抗和2型糖尿病的主要因素，这已成为一个全球性的健康问题。在本研究中，我们使用静息态功能磁共振成像来研究20名瘦男性和20名肥胖男性在饥饿和饱腹状态下自发信号低频波动的幅度。我们发现，在进食前，相对于瘦受试者，肥胖男性楔前叶的基线活动显著增强，而背侧前扣带回皮质（dACC）的活动减弱。此外，进食后，肥胖男性dACC的活动明显低于瘦男性。我们还发现，进食前楔前叶激活与饥饿评分之间存在显著正相关，而进食前后dACC的活动与血浆胰岛素水平呈负相关。这些结果表明，楔前叶和dACC可能在进食行为中都发挥着重要作用。虽然楔前叶似乎介导主观饱腹感，但dACC的水平更能反映葡萄糖利用的间接指标。
