Antalóczy Z, Kekes E
Zhongguo Yao Li Xue Bao. 1989 May;10(3):222-6.
A double blind, randomised crossover study with 20 patients was performed to compare the antianginal effects of atenolol 100 mg once daily and pindolol 5 mg thrice daily. After a placebo run-in period, 2 treatments were given for 2 wk each. The number of anginal attacks and the nitroglycerin (NTG) consumption were determined. During bicycle exercise testing, the systolic blood pressure (BP), heart rate (HR), double product and exercise tolerance were measured. Both drugs reduced the number of anginal attacks and NTG consumption relative to the placebo, with atenolol being more effective than pindolol. During exercise, both beta-blockers produced a slight increase in BP and HR compared to the placebo. HR attained with atenolol was lower than pindolol at the same workload. The total duration of exercise and the maximal tolerated workload were greater in atenolol than pindolol experiment. The special properties of beta-blockers, such as cardioselectivity or intrinsic sympathomimetic activity (ISA), may have clinical importance in the treatment of angina pectoris.
进行了一项双盲、随机交叉研究，纳入20例患者，比较每日一次服用100 mg阿替洛尔与每日三次服用5 mg吲哚洛尔的抗心绞痛效果。经过安慰剂导入期后，每种治疗各给予2周。确定心绞痛发作次数和硝酸甘油（NTG）消耗量。在自行车运动试验期间，测量收缩压（BP）、心率（HR）、双乘积和运动耐量。与安慰剂相比，两种药物均减少了心绞痛发作次数和NTG消耗量，阿替洛尔比吲哚洛尔更有效。在运动期间，与安慰剂相比，两种β受体阻滞剂均使BP和HR略有升高。在相同工作量下，阿替洛尔达到的HR低于吲哚洛尔。阿替洛尔试验中的运动总时长和最大耐受工作量均大于吲哚洛尔试验。β受体阻滞剂的特殊性质，如心脏选择性或内在拟交感活性（ISA），在心绞痛治疗中可能具有临床重要性。
