Valnegri Pamela, Puram Sidharth V, Bonni Azad
Department of Anatomy and Neurobiology, Washington University in St Louis School of Medicine, St Louis, MO 63110, USA; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Trends Neurosci. 2015 Jul;38(7):439-47. doi: 10.1016/j.tins.2015.05.003. Epub 2015 Jun 20.
Dendrites play a central role in the integration and flow of information in the nervous system. The morphogenesis and maturation of dendrites is hence an essential step in the establishment of neuronal connectivity. Recent studies have uncovered crucial functions for extrinsic cues in the development of dendrites. We review the contribution of secreted polypeptide growth factors, contact-mediated proteins, and neuronal activity in distinct phases of dendrite development. We also highlight how extrinsic cues influence local and global intracellular mechanisms of dendrite morphogenesis. Finally, we discuss how these studies have advanced our understanding of neuronal connectivity and have shed light on the pathogenesis of neurodevelopmental disorders.
树突在神经系统信息的整合与传递中发挥着核心作用。因此，树突的形态发生和成熟是建立神经元连接的关键步骤。最近的研究揭示了外在信号在树突发育中的重要作用。我们综述了分泌型多肽生长因子、接触介导蛋白以及神经元活动在树突发育不同阶段所起的作用。我们还强调了外在信号如何影响树突形态发生的局部和整体细胞内机制。最后，我们讨论了这些研究如何增进了我们对神经元连接的理解，并为神经发育障碍的发病机制提供了线索。
