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肥胖是否会影响腰椎管狭窄减压手术后的疗效?一项基于多中心、观察性注册研究。

Does Obesity Affect Outcomes After Decompressive Surgery for Lumbar Spinal Stenosis? A Multicenter, Observational, Registry-Based Study.

作者信息

Giannadakis Charalampis, Nerland Ulf S, Solheim Ole, Jakola Asgeir S, Gulati Michel, Weber Clemens, Nygaard Øystein P, Solberg Tore K, Gulati Sasha

机构信息

Department of Neurosurgery, St. Olavs University Hospital, Trondheim, Norway; Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway.

Department of Neurosurgery, St. Olavs University Hospital, Trondheim, Norway; Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway.

出版信息

World Neurosurg. 2015 Nov;84(5):1227-34. doi: 10.1016/j.wneu.2015.06.020. Epub 2015 Jun 20.

Abstract

OBJECTIVE

To evaluate the association between obesity and outcomes 1 year after laminectomy or microdecompression for lumbar spinal stenosis (LSS).

METHODS

The primary outcome measure was the Oswestry Disability Index (ODI). Obesity was defined as body mass index (BMI) ≥ 30. Prospective data were retrieved from the Norwegian Registry for Spine Surgery.

RESULTS

For all patients (n = 1473) the mean improvement in ODI at 1 year was 16.7 points (95% CI 15.7-17.7, P < 0.001). The improvement in ODI was 17.5 points in nonobese and 14.3 points in obese patients (P = 0 .007). Obese patients were less likely to achieve a minimal clinically important difference in ODI (defined as ≥ 8 points improvement) than nonobese patients (62.2 vs. 70.3%, P = 0.013). Obesity was identified as a negative predictor for ODI improvement in a multiple regression analysis (P < 0.001). Nonobese patients experienced more improvement in both back pain (0.7 points, P = 0.002) and leg pain (0.8 points, P = 0.001) measured by numeric rating scales. Duration of surgery was shorter for nonobese patients for both single- (79 vs. 89 minutes, P = 0.001) and 2-level (102 vs. 114 minutes, P = 0.004) surgery. There was no difference in complication rates (10.4% vs. 10.8%, P = 0.84). There was no difference in length of hospital stays for single- (2.7 vs. 3.0 days, P = 0.229) or 2-level (3.5 vs. 3.6 days, P = 0.704) surgery.

CONCLUSIONS

Both nonobese and obese patients report considerable clinical improvement 1 year after surgery for LSS, but improvement was less in obese patients. Obese patients were less likely to achieve a minimal clinically important difference.

摘要

目的

评估腰椎管狭窄症(LSS)行椎板切除术或显微减压术后1年肥胖与预后的相关性。

方法

主要结局指标为奥斯威斯功能障碍指数(ODI)。肥胖定义为体重指数(BMI)≥30。前瞻性数据取自挪威脊柱外科登记处。

结果

所有患者(n = 1473)术后1年ODI平均改善16.7分(95%可信区间15.7 - 17.7,P < 0.001)。非肥胖患者ODI改善17.5分,肥胖患者为14.3分(P = 0.007)。与非肥胖患者相比,肥胖患者达到ODI最小临床重要差异(定义为改善≥8分)的可能性更小(62.2%对70.3%,P = 0.013)。在多元回归分析中,肥胖被确定为ODI改善的负性预测因素(P < 0.001)。非肥胖患者在采用数字评定量表测量的背痛(改善0.7分,P = 0.002)和腿痛(改善0.8分,P = 0.001)方面改善更多。非肥胖患者单节段手术(79对89分钟,P = 0.001)和双节段手术(102对114分钟,P = 0.004)的手术时间均较短。并发症发生率无差异(10.4%对10.8%,P = 0.84)。单节段手术(2.7对3.0天,P = 0.229)或双节段手术(3.5对3.6天,P = 0.704)的住院时间无差异。

结论

LSS术后1年,非肥胖和肥胖患者均报告有显著的临床改善,但肥胖患者改善较少。肥胖患者达到最小临床重要差异的可能性更小。

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